4-hydroxy-L-tryptophan + H⁺ → 4-hydroxytryptamine + CO₂ (R11678)
- Overexpression
  - Plasmid
4-hydroxytryptamine + S-adenosyl-L-methionine → norpsilocin + S-adenosyl-L-homocysteine (R00884)
- Overexpression
  - Plasmid
    - Escherichia coli PP12
norpsilocin + S-adenosyl-L-methionine → psilocin + S-adenosyl-L-homocysteine (R00885)
- Overexpression
  - Plasmid
    - Escherichia coli PP12
baeocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + psilocybin + H⁺ (R7076)
- Overexpression
  - Plasmid
norbaeocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + baeocystin + H⁺ (R11021)
- Overexpression
  - Plasmid
H₂O + L-methionine + ATP → S-adenosyl-L-methionine + diphosphate + phosphate (R279)
- Overexpression
  - Plasmid
psilocin → psilocin (R00886)
- Overexpression
  - Plasmid
L-glutamine + chorismate ↔ anthranilate + pyruvate + H⁺ + L-glutamate (R10)
- Feedback insensitive
  - Plasmid
    - Escherichia coli PP28
- Overexpression
  - Plasmid
    - Escherichia coli PP28
N-(5-phosphoribosyl)-anthranilate + diphosphate ↔ anthranilate + 5-phospho-α-D-ribose 1-diphosphate (R423)
- Overexpression
  - Plasmid
    - Escherichia coli PP28
1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate + H⁺ → H₂O + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO₂ (R600)
- Overexpression
  - Plasmid
    - Escherichia coli PP28
N-(5-phosphoribosyl)-anthranilate → 1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate (R562)
- Overexpression
  - Plasmid
    - Escherichia coli PP28
L-serine + indole → H₂O + L-tryptophan (R747)
- Overexpression
  - Plasmid
    - Escherichia coli PP28
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate ↔ D-glyceraldehyde 3-phosphate + indole (R503)
- Overexpression
  - Plasmid
    - Escherichia coli PP28