carbamoyl phosphate + L-aspartate ↔ N-carbamoyl-L-aspartate + H⁺ + phosphate (R258)
- Overexpression
  - Genome
H₂O + (S)-dihydroorotate ↔ N-carbamoyl-L-aspartate + H⁺ (R27)
- Overexpression
  - Genome
ATP + H₂O + L-glutamine + hydrogencarbonate ↔ H⁺ + ADP + carbamoyl phosphate + L-glutamate + phosphate (R53)
- Overexpression
  - Genome
- Feedback insensitive
  - Genome
(S)-dihydroorotate + oxygen → orotate + hydrogen peroxide (R414)
- Overexpression
  - Genome
orotidine 5'-phosphate + H⁺ → UMP + CO₂ (R593)
- Overexpression
  - Genome
orotidine 5'-phosphate + diphosphate ↔ 5-phospho-α-D-ribose 1-diphosphate + orotate (R680)
- Overexpression
  - Genome
uridine + GTP → UMP + H⁺ + GDP (R132)
- Silencing
  - Genome
uridine + ATP ↔ UMP + H⁺ + ADP (R136)
- Silencing
  - Genome
uridine + phosphate ↔ α-D-ribose-1-phosphate + uracil (R347)
- Silencing
  - Genome
H2O + uridine → D-ribose + uracil (R00730)
- Silencing
  - Genome
L-ornithine + carbamoyl phosphate ↔ L-citrulline + H⁺ + phosphate (R134)
- Silencing
  - Genome
phosphate + oxaloacetate ↔ phosphoenolpyruvate + hydrogencarbonate (R390)
- Overexpression
  - Genome
L-aspartate + ATP → L-aspartyl-4-phosphate + ADP (R295)
- Silencing
  - Genome
L-homoserine + NAD(P)+ ← L-aspartate 4-semialdehyde + NAD(P)H + H⁺ (R234)
- Silencing
  - Genome
aldehydo-D-ribose 5-phosphate + ATP ↔ 5-phospho-α-D-ribose 1-diphosphate + H⁺ + AMP (R115)
- Overexpression
  - Genome
    - Escherichia coli UR5-2
    - Escherichia coli UR6
uridine + H⁺ ↔ uridine + H⁺ (R00825)
- Silencing
  - Genome
    - Escherichia coli UR6