• acetyl-CoA ↔ coenzyme A + acetoacetyl-CoA (R12)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • H2O + acetoacetyl-CoA + acetyl-CoA ↔ coenzyme A + H+ + (S)-3-hydroxy-3-methylglutaryl-CoA (R685)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • NADPH + squalene + H+ + oxygen → H2O + NADP+ + (3S)-2,3-epoxy-2,3-dihydrosqualene (R823)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • (R)-mevalonate + ATP ↔ (R)-5-phosphomevalonate + H+ + ADP (R630)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • (R)-5-phosphomevalonate + ATP ↔ (R)-mevalonate diphosphate + ADP (R716)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • (R)-mevalonate diphosphate + ATP → isopentenyl diphosphate + phosphate + ADP + CO2 (R465)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • isopentenyl diphosphate ↔ prenyl diphosphate (R123)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • isopentenyl diphosphate + prenyl diphosphate ↔ diphosphate + geranyl diphosphate (R315)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • geranyl diphosphate → (4S)-limonene + diphosphate (R3865)
    • Overexpression
      • Plasmid
        • Escherichia coli EcoCTs03
        • Escherichia coli HK overexpressed
        • Escherichia coli LDH KO
        • Escherichia coli ALDH-ADH KO
  • NAD+ + (R)-lactate ← NADH + pyruvate + H+ (R504)
    • Silencing
      • Genome
        • Escherichia coli LDH KO
  • ethanol + NAD+ ↔ acetaldehyde + NADH + H+ (R157)
    • Silencing
      • Genome
        • Escherichia coli ALDH-ADH KO
  • coenzyme A + acetaldehyde + NAD+ ↔ NADH + H+ + acetyl-CoA (R156)
    • Silencing
      • Genome
        • Escherichia coli ALDH-ADH KO
  • ATP + D-Glucose → ADP + D-glucopyranose 6-phosphate + H+ (R00472)
    • Feedback insensitive
      • Plasmid
        • Escherichia coli HK overexpressed