β-D-glucose 6-phosphate + NADP⁺ → 6-phospho D-glucono-1,5-lactone + NADPH + H⁺ (R392)
- Silencing
  - Genome
D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate ↔ D-erythrose 4-phosphate + β-D-fructofuranose 6-phosphate (R492)
- Overexpression
  - Genome
5-phospho-β-D-ribosylamine + L-glutamate + diphosphate ↔ 5-phospho-α-D-ribose 1-diphosphate + H₂O + L-glutamine (R11)
- Overexpression
  - Genome
  - Plasmid
    - Escherichia coli BL21(DE3) purF
aldehydo-D-ribose 5-phosphate + ATP ↔ 5-phospho-α-D-ribose 1-diphosphate + H⁺ + AMP (R115)
- Feedback insensitive
  - Genome
- Overexpression
  - Genome
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP → 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole + H⁺ + phosphate + ADP (R327)
- Overexpression
  - Plasmid
    - Escherichia coli BL21(DE3) purC
  - Genome
β-D-fructofuranose 6-phosphate + ATP → β-D-fructose 1,6-bisphosphate + H⁺ + ADP (R252)
- Silencing
  - Genome
H₂O + NAD⁺ + IMP ↔ NADH + H⁺ + XMP (R221)
- Silencing
  - Genome
L-aspartate + IMP + GTP → H⁺ + adenylo-succinate + phosphate + GDP (R244)
- Silencing
  - Genome
H₂O + IMP → inosine + phosphate (R580)
- Silencing
  - Genome
N⁵-carboxyaminoimidazole ribonucleotide → 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate (R1103)
- Overexpression
  - Genome
diphosphate + IMP ← 5-phospho-α-D-ribose 1-diphosphate + hypoxanthine (R542)
- Overexpression
  - Genome
    - Escherichia coli AKN17
    - Escherichia coli AKN16
H₂O + glycine + 5,10-methylene-tetrahydromethanopterin ↔ tetrahydromethanopterin + L-serine (R10280)
- Overexpression
  - Genome
    - Escherichia coli AKN17