• L-tyrosine → 4-coumarate + ammonium (R3408)
  • Overexpression
    • Plasmid
      • Escherichia coli BMF2
• coenzyme A + trans-cinnamate + ATP → (E)-cinnamoyl-CoA + diphosphate + AMP (R1946)
  • Overexpression
    • Plasmid
      • Escherichia coli BMF2
• naringenin chalcone → (2S)-naringenin (R11742)
  • Overexpression
    • Plasmid
      • Escherichia coli BMF2
• H⁺ + malonyl-CoA + (E)-4-coumaroyl-CoA → CO₂ + coenzyme A + naringenin chalcone (R8128)
  • Overexpression
    • Plasmid
      • Escherichia coli BMF2
• coenzyme A + acetate + ATP ↔ acetyl-CoA + diphosphate + AMP (R1142)
  • Overexpression
    • Plasmid
      • Escherichia coli BMF2
• (2S)-naringenin + NADPH + oxygen ↔ H₂O + NADP⁺ + (2S)-eriodictyol (R3505)
  • Overexpression
    • Plasmid
      • Escherichia coli BMF2