coenzyme A + 4-coumarate + ATP → (E)-4-coumaroyl-CoA + diphosphate + AMP (R2776)
- Overexpression
  - Plasmid
H⁺ + malonyl-CoA + (E)-4-coumaroyl-CoA → CO₂ + coenzyme A + naringenin chalcone (R8128)
- Overexpression
  - Plasmid
naringenin chalcone → (2S)-naringenin (R11742)
- Overexpression
  - Plasmid
    - Escherichia coli B-AP2
    - Escherichia coli B-AP3
(2S)-naringenin + 2-oxoglutarate + oxygen → H₂O + H⁺ + succinate + CO₂ + apigenin (R10337)
- Overexpression
  - Plasmid